自纽约事件以来,托尼·斯塔克(小罗伯特·唐尼 Robert Downey Jr. 饰)为前所未有的焦虑症所困扰。他疯狂投入钢铁侠升级版的研发,为此废寝忘食,甚至忽略了女友佩珀·波茨(格温妮斯·帕特洛 Gwyneth Paltrow 饰)的感受。与此同时,臭名昭著的恐怖头目曼达林(本·金斯利 Ben Kingsley 饰)制造了一连串的爆炸袭击事件,托尼当年最忠诚的保镖即在最近的一次袭击中身负重伤。未过多久,托尼、佩珀以及曾与他有过一面之缘的女植物学家玛雅(丽贝卡·豪尔 Rebecca Hall 饰)在家中遭到猛烈的炮火袭击,几乎丧命,而这一切似乎都与22年前那名偶然邂逅的科学家阿尔德里奇·基连(盖·皮尔斯 Guy Pearce 饰)及其终极生物的研究有关。
即使有精密先进的铠甲护身,也无法排遣发自心底的焦虑。被击碎一切的托尼,如何穿越来自地狱的熊熊烈火……
影片改编自尼克·托切斯的同名小说,讲述两个平行故事,分别围绕著名诗人但丁和他的代表作《神曲》展开:当代纽约,《神曲》原稿出现在一个黑市走私团伙的手中,厌倦现状的学者尼克(奥斯卡·伊萨克 Oscar Isaac 饰)被他们召唤去辨别真伪。尼克最终因诱惑而违抗黑手党偷走了手稿,和他的爱人茱丽叶塔(盖尔·加朵 Gal Gadot 饰)踏上了一条黑暗暴力之路,从隐喻式的地狱到天堂。 平行时空,但丁(奥斯卡·伊萨克 Oscar Isaac 饰)受困于和杰玛(盖尔·加朵 Gal Gadot 饰)的无爱婚姻,他逃到西西里岛创作了自己最伟大的作品《神曲》,使他逝去的爱人碧翠斯永垂不朽。 尼克和但丁的时间线编织不同的道路,但两人又紧密相连——都迷失在了在对爱、美和上帝预示的追逐中。
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